The evolution of lncRNA repertoires and expression patterns in tetrapods

ABSTRACT: Only a minuscule fraction of long non-coding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but comparative analyses have been precluded by our ignorance of lncRNAs in non-model organisms. Here, we use RNA sequencing to identify lncRNAs in eleven tetrapod species and we present the first large-scale evolutionary study of lncRNA repertoires and expression patterns. We identify ~11,000 primate- specific lncRNA families, which show evidence for selective constraint during recent evolution, and ~2,400 highly conserved lncRNAs (including ~400 genes that likely originated more than 300 million years ago). We find that lncRNAs, in particular ancient ones, are generally actively regulated and may predominantly function in e

ORGANISM(S): Ornithorhynchus anatinus

SUBMITTER: Anamaria Necsulea 

PROVIDER: E-GEOD-43520 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress