Evolutionary analysis across mammals reveals distinct classes of long noncoding RNAs

ABSTRACT: Recent advances in transcriptome sequencing have enabled the discovery of thousands of long non-coding RNAs (lncRNAs) across many species. Though several lncRNAs have been shown to play important roles in diverse biological processes, the functions and mechanisms of most lncRNAs remain unknown. Two significant obstacles lie between transcriptome sequencing and functional characterization of lncRNAs: identifying truly non-coding genes from de novo reconstructed transcriptomes, and prioritizing the hundreds of resulting putative lncRNAs for downstream experimental interrogation. We present slncky, a computational lncRNA discovery tool that produces a high-quality set of lncRNAs from RNA-sequencing data and further uses evolutionary constraint to prioritize lncRNAs that are likely to be funct

ORGANISM(S): Homo sapiens

SUBMITTER: Jenny Chen 

PROVIDER: E-GEOD-64818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress