Non-canonical TSSs of TEs alter gene structure and expression in Drosophila melanogaster

ABSTRACT: Background: Transposable elements (TEs) represent a substantial fraction of the genomes, playing a major role in evolution, as sources of genetic variability. To fully appraise the role of TE in the acquisition of genetic novelty in genome evolution, we must also consider the impact of their own transcriptional activity. Results: We studied impact of TE transcriptional activity on gene using high-throughput RNA-Seq sequencing in Drosophila melanogaster. TEs, which turn out to be expressed in euchromatin as well as in heterochromatin, interact with genes at different levels. The observed transcription from TEs involve canonical or non-canonical transcription start sites (TSSs) distributed along their sequence. We also find evidences for potential bidirectional transcription from the TE prom

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthias Zytnicki 

PROVIDER: E-GEOD-52472 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress