Seeking genes responsible for developmental origins of health and disease from the fetal mouse liver following maternal food restriction [Methylation]

ABSTRACT: Non-optimal fetal environments resulting in low birth weight have epidemiologically been associated with a higher risk of adult diseases. In animal models, maternal undernutrition has successfully demonstrated that offspring owed increased risks for adult diseases. In mice, shorten life span was also demonstrated in offspring following maternal undernutrition. In the present study, we treated pregnant mice with 50% food restriction (FR), and performed global gene expression and promotor DNA methylation profiling on the fetal livers. Considering that effects of food restriction is opposite between before and after birth, we further searched genes which are regulated oppositely against adult calorie restriction (CR) and commonly against aging. Among searched genes, trib1 has already been dem

ORGANISM(S): Mus musculus

SUBMITTER: Randeep Rakwal 

PROVIDER: E-GEOD-52517 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress