Searching genes responsible for developmental origins of health and disease (DOHaD) by comparing adult and fetal mouse undernutrition models

ABSTRACT: A large number of rodent studies have supported the developmental origins of health and disease (DOHaD) hypothesis that interauterine undernutrition (IU) is a risk factor for non-communicable diseases. The effect of IU is considered to be induced thorough epigenetic programming in the fetal tissues. We have recently carried out global transcriptome expression and promoter DNA methylation analyses on the fetal mouse liver following maternal 50% food restriction (FR) during late gestation, and reported a list of fetal liver genes that were transcriptionally or epigenetically regulated by IU (Ogawa et al., 2014, Congenital Anomalies). We have already reported the genes that were regulated oppositely between maternal and fetal livers (Ogawa et al., 2014, Congenital Anomalies). Here, we conside

ORGANISM(S): Mus musculus

SUBMITTER: RANDEEP RAKWAL 

PROVIDER: E-GEOD-78817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress