The long non-coding RNA Paupar regulates the expression of both local and distal genes [Paupar KD]

ABSTRACT: Although some long noncoding RNAs (lncRNAs) have been shown to regulate gene expression in cis, it remains unclear whether lncRNAs can directly regulate transcription in trans by interacting with chromatin genome-wide independently of their sites of synthesis. Here, we describe the genomically local and more distal functions of Paupar, a vertebrate-conserved and central nervous system-expressed lncRNA transcribed from a locus upstream of the gene encoding the Pax6 transcription factor. Knockdown of Paupar disrupts the normal cell cycle profile of neuroblastoma cells and induces neuronal differentiation. Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical associatio

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Sansom 

PROVIDER: E-GEOD-52569 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress