Effects of an antipsychotic (Olanzapine) involves alterations in gene specific DNA methylation

ABSTRACT: Antipsychotic drugs are commonly used to treat psychosis, mood disorders, and anxiety. While there is indirect evidence that some component of the antipsychotic effect of these drugs may involve modulation of dopamine transmission, their mechanism of action is poorly understood. We hypothesized that antipsychotic drugs mediate their effects via epigenetic modulation. Here we tested the effect of an antipsychotic, olanzapine, on the methylation status of genes following chronic treatment. These effects have been revealed through significantly increased (p<0.01) DNA methylation of genes involved in dopaminergic and non-dopaminergic pathways including the glutamatergic, GABAergic, cholinergic, neuregulin and ErbB signaling pathways. The affected genes included GLS in hippocampus, NR1 in cereb

ORGANISM(S): Rattus norvegicus

SUBMITTER: Melkaye Melka 

PROVIDER: E-GEOD-52615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress