Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Epstein Barr Virus Nuclear Antigen 3C binds to BATF/IRF4/SPI1 sites and represses CDKN2A by recruiting Sin3A

ABSTRACT: We report the application of ChIP Seq to study the Epstein Barr Virus Nuclear Antigen 3C, an essential transcriptional regulator involved in the transformation of Resting B Lymphocytes to the immortalized Lymphoblast Cell Lines Examination of viral and cellular transcription factors in 1 type of cell line

ORGANISM(S): Homo sapiens

SUBMITTER: Hufeng Zhou 

PROVIDER: E-GEOD-52632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A.

Jiang Sizun S   Willox Bradford B   Zhou Hufeng H   Holthaus Amy M AM   Wang Anqi A   Shi Tommy T TT   Maruo Seiji S   Kharchenko Peter V PV   Johannsen Eric C EC   Kieff Elliott E   Zhao Bo B  

Proceedings of the National Academy of Sciences of the United States of America 20131216 1

Epstein-Barr virus nuclear antigen 3C (EBNA3C) repression of CDKN2A p14(ARF) and p16(INK4A) is essential for immortal human B-lymphoblastoid cell line (LCL) growth. EBNA3C ChIP-sequencing identified >13,000 EBNA3C sites in LCL DNA. Most EBNA3C sites were associated with active transcription; 64% were strong H3K4me1- and H3K27ac-marked enhancers and 16% were active promoters marked by H3K4me3 and H3K9ac. Using ENCODE LCL transcription factor ChIP-sequencing data, EBNA3C sites coincided (±250 bp)  ...[more]

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