Time series expression data following miR-9 inhibition

ABSTRACT: A high-resolution time series study of transcriptome dynamics following antimiR--mediated inhibition of miR-9 in a Hodgkin lymphoma cell-line revealed both general and miR-9 specific aspects of the miRNA--mediated post--transcriptional dynamic response.MiR-9 inhibition induced a multiphasic gene response, with an initial direct response at approximately 4 hours and multiple later responses which showed transcription factor enrichments indicative of indirect causally downstream responses, and an overall shift of gene product function from predominantly mRNA processing at early time points to translation at later time points. The full time course used was: 2,4,6,8,10,12,14,16,18,20,22,26,32,40,56,80,112 hours post-miR-9 inhibition. Microarrays were Affymetrix HuGene-10-st-v1. Each LNA-ant

ORGANISM(S): Homo sapiens

SUBMITTER: Jiayu Wen 

PROVIDER: E-GEOD-52710 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress