Increased expression of c-Jun in nonalcoholic fatty liver disease

ABSTRACT: Background & Aims: Overnutrition is one of the major causes of non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH). Besides the quantity of consumed calories, distinct dietary components are increasingly recognized as important contributor to the pathogenesis of NASH. We aimed to develop and characterize a hitherto missing murine model which resembles both the pathology and nutritional situation of NASH-patients in Western societies. Methods: We developed a NASH-inducing diet (ND) enriched with sucrose, cholesterol and a high concentration of fats rich in saturated fatty acids in a composition which mimics Western food. C57Bl6/N mice were fed with the ND or control chow for 12 weeks. Biochemical, real-time polymerase chain reaction, Western

ORGANISM(S): Mus musculus

SUBMITTER: Claus Hellerbrand 

PROVIDER: E-GEOD-52748 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress