Pathway analysis of microRNA expression profile during murine osteoclastogenesis

ABSTRACT: Osteoclasts are multinucleated cells specialized in degrading the mineralized bone matrix. Osteoclast differentiation and function are tightly regulated, to prevent excessive or insufficient bone resorption. Several control mechanisms participate in modulating osteoclastogenesis, and an increasing number of reports describe the role of microRNAs (miRNAs) in this process. Disrupting the expression of specific miRNAs can result in alterations of osteoclast formation and bone homeostasis. We and others have previously characterized 9 miRNAs whose levels change during osteoclast differentiation, and identified some of the target genes that mediate their function. However, little is known about changes in the miRNA expression profile during osteoclastogenesis. In this study, we isolated a murin

ORGANISM(S): Mus musculus

SUBMITTER: Anne Delany 

PROVIDER: E-GEOD-53017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress