Microarray profile of p62P392L-regulated gene expression in RANKL and M-CSF stimulated normal human bone marrow derived non-adherent cells

ABSTRACT: Paget’s disease of bone (PDB) is a chronic focal skeletal disorder that affects 2-3% of the population over the age of 60. PDB is inherited as an autosomal dominant trait with genetic heterogeneity. SQSTM1/p62 UBA domain mutation (p62P392L) is widely identified in PDB and has been shown to increase osteoclastogenesis. Further, environmental factors such as paramyxovirus are implicated in PDB and MVNP has been shown to induce Pagetic phenotype in osteoclasts. However, the molecular mechanisms underlying p62P392L and MVNP stimulation of osteoclast differentiation in PDB are unclear. We therefore determined p62P392L regulated gene expression profiling during osteoclast differentiation. We identified 9.7% genes were upregulated (> 4-fold) in p62P392L transduced cells. P62P392L mutant increas

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Falduto 

PROVIDER: E-GEOD-29107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress