Transcription profiling of rat smooth muscle cells modulated by rapamycin and paclitaxel

ABSTRACT: Background: Drug-eluting stents (DES) have rapidly become a standard therapy for treatment of obstructive coronary artery disease. Differences exist in therapeutic responses to different DES formulations, and mechanisms to predict drug responses in the preclinical setting have not been standardized. Results: We have used gene expression profiling to characterize the patterns of gene regulation within cultures of rat aortic smooth muscle cells (RASMC) treated with rapamycin or paclitaxel, the two drugs widely used in commercially available DES. These studies further validate the use of the in vitro RASMC culture system as a model of insulin resistance. Gene expression profiles easily distinguish RASMC grown under normal or high glucose conditions, and we therefore followed this approach in

ORGANISM(S): Rattus norvegicus

SUBMITTER: Peter Charles 

PROVIDER: E-GEOD-5337 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress