Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Katia Georgopoulos
PROVIDER: E-GEOD-53401 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Joshi Ila I Yoshida Toshimi T Jena Nilamani N Qi Xiaoqing X Zhang Jiangwen J Van Etten Richard A RA Georgopoulos Katia K
Nature immunology 20140209 3
Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL). Here we found that conditional inactivation of the Ikaros DNA-binding domain in early pre-B cells arrested their differentiation at a stage at which integrin-dependent adhesion to niches augmented signaling via mitogen-activated protein kinases, proliferation an ...[more]