Gene expression profiling of 4T1-SP and 4T1-NSP cells

ABSTRACT: Novel therapies targeting cancer stem cells (CSCs), which play critical roles in chemo- and radio-resistance, metastasis, and possibly resistance against cancer immunotherapy including granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced tumor cell vaccines, may provide beneficial clinical outcomes. Here, we used syngeneic immunocompetent mice that allowed precise evaluation of the immunogenicity of the side population (SP) isolated from 4T1 murine breast carcinoma (4T1-SP) cells as putative CSCs. 4T1-SP cells showed various stem cell properties including high capacities for colony formation and tumorigenicity as well as high expression of phosphorylated signal transducer and activator of transcription-3 and vascular endothelial growth factor that are inductive of immu

ORGANISM(S): Mus musculus

SUBMITTER: kenzaburo tani 

PROVIDER: E-GEOD-53444 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress