Profiling of Lola-N genomic binding in Drosophila with DamID

ABSTRACT: The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated state. Transcription factors that specify neuronal characteristics have been well studied but less is known about the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state. Here we identify Lola as a transcription factor that is required to maintain neurons in a differentiated state. We show that Lola represses neural stem cell genes and cell cycle genes in post-mitotic neurons. In lola mutants, neurons dedifferentiate, turn on neural stem cell genes and begin to divide, forming tumours. Thus, neurons rather than ste

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Tony Southall 

PROVIDER: E-GEOD-53447 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress