Involvement of Nr4a in a Treg-specific transcriptional program and suppression ofM-cM-^@M-^@Th2/Tfh response

ABSTRACT: Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many aspects of immune system physiology and pathophysiology. Treg cells are characterized by a distinct pattern of gene expression, including upregulation of immune-suppressive genes and silencing of inflammatory cytokine genes. However, the molecular mechanisms that establish and/or maintain such gene regulation in Treg cells remain largely unknown. We recently reported that Nr4a family nuclear orphan receptors are essential for the development of Treg cells. The fact that Treg cells maintain high levels of expression of all Nr4a family components suggests that they may also play critical roles beyond Treg cell development. Here, we show that Nr4a factors are essential for maintaining Treg-specif

ORGANISM(S): Mus musculus

SUBMITTER: Takashi Sekiya 

PROVIDER: E-GEOD-53574 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress