The role of Ch25h in the macrophage response to poly(I:C) (bone-marrow-derived macrophages)

ABSTRACT: Cross-talk between sterol regulatory pathways and inflammatory pathways has been demonstrated to play an important role in the response to viral infections. 25-Hydroxycholesterol (25HC) is an oxysterol that plays multiple roles in lipid biosynthesis and immunity, and has recently been shown to have anti-viral activity. Surprisingly, we found that deletion of Ch25h, the gene encoding the enzyme responsible for 25HC production, is protective in a mouse model of influenza infection as a result of decreased inflammatory-induced pathology. Anti-viral responses involve complex gene regulatory circuits with multiple feedback loops and we demonstrated that 25HC acts as an amplifier of TLR3 signaling in macrophages and airway epithelial cells. We determined that 25HC amplifies TLR3 signaling, at

ORGANISM(S): Mus musculus

SUBMITTER: Aderem Lab 

PROVIDER: E-GEOD-54062 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress