Effect of 10 or 25 days cortisol treatment on late gestation fetal septum

ABSTRACT: We have previously shown in sheep that 10 days of modest chronic increase in maternal cortisol result in fetal heart enlargement and Purkinje cell apoptosis. In subsequent studies in which we extended the duration of cortisol infusion (1mg/kg/d) to term, we found a dramatic incidence of stillbirth in the pregnancies with chronically increased cortisol and associated maternal hyperglycemia. To investigate the effects on the heart, transcriptomic analyses were performed on the septa using ovine microarrays and Webgestalt and Cytoscape programs for pathway inference. Analyses of the effects of 10 days of maternal cortisol infusion (130d-cortisol vs 130d control), ~25 days (term at ~140d-cortisol vs 140d control), normal maturation (140d-control vs 130d control) were performed. In all analyse

ORGANISM(S): Ovis aries

SUBMITTER: Maureen Keller-Wood 

PROVIDER: E-GEOD-54237 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress