Microarray analysis of B16 cells in pigmentation oscillator

ABSTRACT: Cellular homeostasis is an outcome of complex interacting processes with nonlinear feedbacks that span spatiotemporal scales. Skin tanning is one such dynamic response that maintains genome integrity of epidermal cells. While pathways underlying hyperpigmentation cascade are recognized, negative feedback regulatory loops that can dampen the activated melanogenesis process are not completely understood. By designing a pigmentation oscillator, in this study we delineate the role of interferon gamma (IFN-γ) signaling in skin pigmentation homeostasis. IFN-γ signaling reversibly controls maturation of the key organelle melanosome by concerted regulation of several pigmentation genes. We show that this temporal effect is mediated through interferon regulatory factor-1 (IRF-1) independent of the

ORGANISM(S): Mus musculus

SUBMITTER: vivek Natarajan 

PROVIDER: E-GEOD-54359 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress