Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sean Cory
PROVIDER: E-GEOD-54532 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Science signaling 20140422 322
The Met receptor tyrosine kinase is activated or genetically amplified in some gastric cancers, but resistance to small-molecule inhibitors of Met often emerges in patients. We found that Met abundance correlated with a proliferation marker in patient gastric tumor sections, and gastric cancer cell lines that have MET amplifications depended on Met for proliferation and anchorage-independent growth in culture. Inhibition of Met induced temporal changes in gene expression in the cell lines, initi ...[more]