TGF β signaling functions as a sugar sensing feedback loop to regulate digestive enzyme expression.

ABSTRACT: Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a potential step to regulate nutriment intake. However, the role of digestion in nutrient homeostasis has been largely neglected. In this study, we analyzed the mechanism underlying glucose repression of amylase in the adult Drosophila midgut. We demonstrated that glucose represses many carbohydrases and lipases. Our data shows that the consumption of nutritious sugars stimulates the secretion of the TGFβ ligand, Dawdle. Dawdle then acts via the circulation to activate TGFβ/Activin signaling in the midgut, culminating in the repression of digestive enzyme expression. Thus, our study not only identifies a mechanism c

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Maroun Bou Sleiman 

PROVIDER: E-GEOD-54755 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress