Transcriptional profiling of Drosophila wing pouch following CR32027 RNAi

ABSTRACT: The eukaryotic cell cycle, driven by both transcriptional and post-translational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. While genome-wide studies have investigated cell cycle-associated transcription in unicellular systems, global patterns of periodic transcription in multicellular tissues remain largely unexplored. Here we define the cell cycle-associated transcriptome of the developing Drosophila wing epithelium and compare it with that of cultured Drosophila S2 cells, revealing a core set of periodic genes as well as a surprising degree of context-specificity in periodic transcription. We further employ RNAi-mediated phenotypic profiling to define functional requirements for over 300 periodic genes, with a focus on those required

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Chris Seidel 

PROVIDER: E-GEOD-54927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress