Time-series of transcriptome analysis of Bacillus subtilis response to 25 mM potassium acetate and 0.85 M-BM-5M CCCP

ABSTRACT: The advent of M-bM-^@M-^XomicsM-bM-^@M-^Y techniques bear significant potential for the assessment of the microbiological stability of foods. This requires the integration of molecular data with their implication for cellular physiology. Here we performed a comparative physiological and transcriptional analysis of Bacillus subtilis stressed with three different weak organic acids: the commonly used food preservatives sorbic- and acetic- acid, plus the well-known uncoupler carbonyl cyanide-m-chlorophenyl hydrazone (CCCP). The concentration of each compound needed to cause a similar reduction of the growth rate negatively correlated with their membrane solubility, and positively with the concentration of undissociated acid. Intracellular acidification was demonstrated by expressing a pH-sens

ORGANISM(S): Bacillus subtilis

SUBMITTER: Alexander Ter Beek 

PROVIDER: E-GEOD-55051 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress