Genome-Wide Profiling of miRNA-mRNA regulatory network in Skeletal Muscle with Aging [mRNA]

ABSTRACT: Skeletal muscle degenerates progressively, loses mass (sarcopenia) along in years, and leads to reduced physical ability, often causing secondary diseases such as diabetes and obesity. It is known that regulation of gene expression by microRNAs is a key event in muscle development and disease. To understand genome-wide changes in microRNAs and mRNAs during muscle aging, we sequenced microRNAs as well as mRNAs from mouse gastrocnemius muscles at two different ages (6 versus 24-month-old). Thirty-four microRNAs (15 up-regulated and 19 down-regulated) were differentially expressed with age among which were microRNAs such as miR-206 or -434 which were differentially expressed in aged muscle in previous studies. Interestingly, seven microRNAs in a microRNA cluster at imprinted Dlk1-Dio3 locus o

ORGANISM(S): Mus musculus

SUBMITTER: Ji Young Kim 

PROVIDER: E-GEOD-55163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress