Major and Minor Group Human Rhinovirus Response in Human Macrophages

ABSTRACT: Major- and minor-group rhinoviruses enter their host by binding to the cell surface molecules ICAM-1 and LDL-R, respectively, which are present on both macrophages and epithelial cells. Although epithelial cells are the primary site of productive HRV infection, previous studies have implicated macrophages in establishing the cytokine dysregulation that occurs during rhinovirus-induced asthma exacerbations. Even though major- and minor-group rhinoviruses are nearly genetically identical, these viruses do not replicate with equal success in monocyte-lineage cell lines. In human primary macrophages, differential mitochondrial activity and signaling pathway activation was observed between major- and minor-group rhinovirus upon initial HRV binding, indicating discordant receptor-dependent respo

ORGANISM(S): Homo sapiens

SUBMITTER: Michal Mokry 

PROVIDER: E-GEOD-55271 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress