Transcription profiling of human CD14+ peripheral blood monocytes from subjects infected with H.drcreyi reveals host susceptibility to H. ducreyi infection is associated with unique transcript profiles in tissue and dendritic cells

ABSTRACT: Comparison of gene expression from subjects who resolved or formed pustules to H.ducreyi. In human inoculation experiments, the cutaneous immune response to Haemophilus ducreyi consists of serum, PMN, macrophages, T cells and myeloid DC. In reinfection experiments, some subjects form pustules twice (PP group) or resolve infection twice (RR group). Although pustule formation is associated with serum resistance and phagocytic failure, there are no differences in the ability of isolated phagocytes or serum obtained from PP and RR subjects to ingest or kill H. ducreyi. To identify the basis for differential host susceptibility to H. ducreyi, we used microarrays to profile gene expression in infected and uninfected tissue and monocyte-derived DC obtained from PP and RR subjects. In infected

ORGANISM(S): Homo sapiens

SUBMITTER: Stanley Spinola 

PROVIDER: E-GEOD-5547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress