MicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis

ABSTRACT: Background: Psoriasis is a systemic inflammatory skin disease. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that recently have been found in the blood to be relevant as disease biomarkers. Objective: We aimed to explore miRNAs potential as blood biomarkers for psoriasis. Methods: Using microarray and quantitative real-time PCR we measured the global miRNA expression in whole blood, plasma and peripheral blood mononuclear cells (PBMCs) from patients with psoriasis and healthy controls. Results: We identified several deregulated miRNAs in the blood from patients with psoriasis including miR-223 and miR-143 which were found to be significantly upregulated in the PBMCs from patients with psoriasis compared with healthy controls (FCH=1.63, P<0.01; FCH=2.18, P<0.01, respectiv

ORGANISM(S): Homo sapiens

SUBMITTER: Marianne Løvendorf 

PROVIDER: E-GEOD-55515 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress