Gene expression profiling of African American vs European American HPV-negative oropharyngeal squamous cell carcinomas

ABSTRACT: Head and neck cancer (HNC) is the fifth most common malignancy worldwide with an annual mortality rate of 200,000. About 90% of HNC can be classified as head and neck squamous cell carcinomas (HNSCC), of which approximately 75% are attributed to alcohol and tobacco consumption and 25% are associated with human papillomavirus (HPV), predominantly HPV16. HPV-associated OPC have better prognosis and a more favorable response to therapy as compared to HPV-negative tumors. Differences in risk factors, age of presentation, clinical behavior and gene expression profiles indicate that HPV-positive and HPV-negative tumors develop via different molecular mechanisms and are biologically distinct. African American (AA) males have a higher incidence of HNC than any other racial/gender group, and a mo

ORGANISM(S): Homo sapiens

SUBMITTER: Kim Creek 

PROVIDER: E-GEOD-55543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress