Genomewide investigation of pre-invasive and invasive epithelial changes in human papillomavirus associated oropharyngeal carcinoma

ABSTRACT: Background: The incidence of human papillomavirus (HPV) associated oropharyngeal carcinomas has increased rapidly over the last thirty years. These tumours behave as a distinct biological entity when compared to classical smoking- and alcohol-related disease. To gain more information regarding the pathway through pre-malignancy in HPV positive/HPV negative oropharyngeal carcinoma (OSCC), we investigated genomewide expression profiles in histopathologically confirmed tumour samples with site-matched normal epithelial controls. Methods: Twenty-four patients with primary oropharyngeal squamous cell carcinoma (4 with stage III and 20 with stage IV disease) were included in this prospective clinical trial (UKCRN11945). The tumour tissues were each assessed by a histopathologist with HPV status

ORGANISM(S): Homo sapiens

SUBMITTER: Liam Masterson 

PROVIDER: E-GEOD-56142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress