Prefrontal cortex gene expression in WSP and WSR male and female mice following chronic ethanol exposure during peak withdrawal at 8hr

ABSTRACT: While women are more vulnerable than men to many of the medical consequences of alcohol abuse, the role of sex in the response to ethanol is controversial. Neuroadaptive responses that result in the hyperexcitability associated with withdrawal from chronic ethanol likely reflect gene expression changes. We have examined both genders for the effects of withdrawal on brain gene expression using mice with divergent withdrawal severity that have been selectively bred from a genetically heterogeneous population. A total of 295 genes were identified as ethanol regulated from each gender of each selected line by microarray analyses. Hierarchical cluster analysis of the arrays revealed that the transcriptional response correlated with sex rather than with the selected withdrawal phenotype. Consist

ORGANISM(S): Mus musculus

SUBMITTER: Kristine Wiren 

PROVIDER: E-GEOD-56249 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress