Rat ventral prostate gland gene profile after androgen deprivation

ABSTRACT: Androgens are required for prostate development, growth and physiology, by activating the androgen receptor (AR) upon activation by testosterone and dihydrotestosterone (DHT), the AR undergoes conformational changes, dimerizes and translocates to the cell nucleus regulation important genes releted to cell survival. Understanding the mechanisms of androgen regulation in the prostate gland is important, because the prostate is affected by several different diseases, in particular prostate cancer (PCa). Several ways exist to treat prostate cancer and promote epithelial cell death. Treatments involving androgen manipulation include surgical castration (bilateral orchiectomy), antiandrogens (usually AR antagonists), or substances that inhibit androgen synthesis (5 alpha-reductase inhibitors, go

ORGANISM(S): Rattus norvegicus

SUBMITTER: Rafaela Ribeiro 

PROVIDER: E-GEOD-56289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress