Wnt1-induced mammary tumor from Rarb KO mice vs. those from Rarb wt (control)

ABSTRACT: Previously we have demonstrated that inactivation of retinoic acid receptor beta (Rarb) in the mouse results in a protective effect against ErbB2-induced mammary gland tumorigenesis although Rarb has been reported as a tumor suppressor before. In the current study, we further confirmed that ablation of Rarb has a very similar impact on Wnt1-induced mammary gland tumorigenesis as those on ErbB2-induced mammary gland tumorigenesis. Nevertheless, the mechanisms by which Rarb confers its effects on tumor progression is quite different although both involving in tumor microenvironment (TME) remodeling. In the Wnt1 tumors, ectopic wnt1 produced by malignant luminal cells activates nearby stromal cells by a paracrine manner. In return, the stromal cells secreted IGF1 to regulate the growth of tum

ORGANISM(S): Mus musculus

SUBMITTER: Xingxing LIU 

PROVIDER: E-GEOD-56391 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress