Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Altered epigenetic programming links intestinal inflammation to colon cancer (RNA-seq)

ABSTRACT: This study uses whole-transcriptome sequencing to characterize the transcriptomes of the AOM/DSS mouse model. In this model, mice are treated with dextran sodium sulfate (DSS) to induce colitis. When this treatment is preceded by injections of the weak carcinogen azoxymethane (AOM) the mice develop intestinal tumors. Our results identify sets of differentially expressed genes which are correlated with methylation changes of the corresponding genes. Whole transcriptome analysis of Mus musculus. Three conditions were sequenced and analyzed, the first is an untreated control, the second corresponds to inflammation induced by applying DSS, the third to cancer induced by inflammation and application of AOM. The control condition as well as the AOM-induced cancer condition were analyzed using three replicates, the second condition using 4 replicates.

ORGANISM(S): Mus musculus

SUBMITTER: Guenter Raddatz 

PROVIDER: E-GEOD-57533 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer.

Abu-Remaileh Monther M   Bender Sebastian S   Raddatz Günter G   Ansari Ihab I   Cohen Daphne D   Gutekunst Julian J   Musch Tanja T   Linhart Heinz H   Breiling Achim A   Pikarsky Eli E   Bergman Yehudit Y   Lyko Frank F  

Cancer research 20150325 10

Chronic inflammation represents a major risk factor for tumor formation, but the underlying mechanisms have remained largely unknown. Epigenetic mechanisms can record the effects of environmental challenges on the genome level and could therefore play an important role in the pathogenesis of inflammation-associated tumors. Using single-base methylation maps and transcriptome analyses of a colitis-induced mouse colon cancer model, we identified a novel epigenetic program that is characterized by  ...[more]

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