Gene Expression Profiling of Patients with a Variation in the TNF-alpha gene and suffering from Multiple Trauma

ABSTRACT: BACKGROUND: Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We undertook a prospective cohort study of trauma patients to examine the role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of sepsis syndrome and mortality. METHODS: 159 severely traumatized patients from a single centre were included. Serial blood samples were analyzed for serum concentrations of TNF-alpha and lymphotoxin alpha (LT-alpha). We genotyped nine polymorphisms in the TNF gene and tested for an association with sepsis syndrome and outcome. Genetic associations were validated in an external replication sample (n=76). We examined the peripheral blood t

ORGANISM(S): Homo sapiens

SUBMITTER: Felix Thierer 

PROVIDER: E-GEOD-5760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress