Transcription profiling of mouse brain region bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum to identify distinct transcriptional patterns.

ABSTRACT: To identify distinct transcriptional patterns between the major subcortical dopamine targets commonly studied in addiction we studied differences in gene expression between the bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAc), and dorsal striatum (dStr) using microarray analysis. We first tested for differences in expression of genes encoding transcripts for common neurotransmitter systems as well as calcium binding proteins routinely used in neuroanatomical delineation of brain regions. This a priori method revealed differential expression of corticotropin releasing hormone (Crh), the GABA transporter (Slc6a1), and prodynorphin (Pdyn) mRNAs as well as several others between. Using a Gene ontology tool, functional scoring analysis, and Ingenuity Pathway Analysis, we f

ORGANISM(S): Mus musculus

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-5763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress