Chromosome as oncogenic organizer: functional consequences of structural mutations in breast cancer (RNA-Seq)

ABSTRACT: Chromosomal structural mutations play an important role in determining the transcriptional landscape of human breast cancers. To assess the nature of these structural mutations, we analyzed a representative sampling of the major types of breast tumor samples for detailed structural mutations using paired-end tag sequencing of long-insert genomic DNA (DNA-PET) with matched transcriptome ascertainment by RNA-seq. Compared with other structural mutations, tandem duplications are enriched around partners of fusion transcripts and demarcate regions of high gene expression. Moreover tandem duplications appear to be early events in tumor evolution by facilitating subsequent downstream amplification and deletion of important adjacent cancer associated genes. In a detailed reconstruction of events

ORGANISM(S): Homo sapiens

SUBMITTER: Edison Liu 

PROVIDER: E-GEOD-57914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress