The transcriptomic responses of THP1 human monocyte-like cells expressing SP110b to interferon gamma stimulation

ABSTRACT: SP110b is an interferon (IFN)-induced nuclear protein and may function as a transcriptional co-activator/repressor. IFNγ activates monocytes/macrophages thereby mediating inflammation. However, uncontrolled activation induces monocyte/macrophage cell death, which may cause immunopathology. We have demonstrated that SP110b expression prevented IFNγ-mediated monocyte/macrophage cell death. To explore the molecular mechanisms by which SP110b suppresses IFNγ-induced cell death, we performed a genome-wide microarray analysis to identify genetic determinants associated with IFNγ-induced cell death and regulated by SP110b. We sought to identify genetic determinants associated with IFNγ-induced cell death and regulated by SP110b. To that end, THP1 human monocyte-like cells that could be induced by

ORGANISM(S): Homo sapiens

SUBMITTER: Bo-Shiun Yan 

PROVIDER: E-GEOD-58096 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress