Epigenetic programming during monocyte to macrophage differentiation and trained innate immunity

ABSTRACT: Monocyte differentiation into macrophages represents one of the cornerstone processes in innate host defense. In addition, immunological imprinting of either tolerance or trained immunity after an initial infection determines the functional fate of innate immune cells and the susceptibility of the host to secondary infections. Here we comprehensively characterize the epigenetic profiles of these functional states relative to healthy adult naM-CM-/ve monocytes. Inflammatory and metabolic pathways are strongly modulated in the derived macrophages, including decreased activation of inflammasome components. The cAMP-dependent signaling pathway is remodeled and adrenergic signaling was functionally implicated in trained innate immunity induction in vivo. Interestingly, M-oM-^AM-"-Glucan trains

ORGANISM(S): Homo sapiens

SUBMITTER: Hindrik Kerstens 

PROVIDER: E-GEOD-58310 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress