Molecular differences between mesenchymal populations from deciduous and permanent human teeth

ABSTRACT: Deciduous and permanent human teeth represent a model system to study ageing of mesenchymal populations. Aging is tightly connected to self-renewal and proliferation and thus, mapping potential molecular differences in these characteristics between populations constitutes an important task. Specifically designed microarray panels were used. We have detected a number of molecules that were differentially expressed in dental pulp mesenchyme from deciduous and permanent teeth extracted from young children and adults, respectively. Among the differentially regulated genes HMGA2, a stem cell-associated marker, stood out as a remarkable example with a robust expression in deciduous pulp cells. In addition to this, we discovered that several proliferation-related genes, including CDC2A and CDK4,

ORGANISM(S): Homo sapiens

SUBMITTER: Paolo Guarnieri 

PROVIDER: E-GEOD-58668 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress