A Dach2-Hdac9-Myog-Gdf5 signaling system regulates regeneration of neuromuscular synapses

ABSTRACT: Muscle denervation due to injury, disease or aging results in impaired motor function. Restoring neuromuscular communication requires axonal regrowth and regeneration of neuromuscular synapses. Muscle activity inhibits neuromuscular synapse regeneration. The mechanism by which muscle activity regulates regeneration of synapses is poorly understood. Dach2 and Hdac9 are activity-regulated transcriptional co-repressors that are highly expressed in innervated muscle and suppressed following muscle denervation. Here, we report that Dach2 and Hdac9 inhibit regeneration of neuromuscular synapses. Importantly, we identified Myog and Gdf5 as muscle-specific Dach2/Hdac9-regulated genes that stimulate neuromuscular regeneration in denervated muscle. Interestingly, Gdf5 also stimulates presynapti

ORGANISM(S): Mus musculus

SUBMITTER: Ana Grant 

PROVIDER: E-GEOD-58669 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress