Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development (RNA-seq)

ABSTRACT: As sex determines mammalian development, understanding the nature and developmental dynamics of the sexually dimorphic transcriptome is important. To explore this, we generated 72 genome-wide RNA-seq profiles from mouse eight-cell embryos, late gestation and adult livers, together with 4 ground-state pluripotent embryonic (ES) cell lines from which we generated both RNA-seq and multiple ChIP-seq profiles. We complemented this with previously published data to yield 5 snap-shots of pre-implantation development, late-gestation placenta and somatic tissue and multiple adult tissues for integrative analysis. We define a high-confidence sex-dimorphic signature of 56 genes in eight-cell embryos. Sex-chromosome-linked components of this signature are largely conserved throughout pre-implantation

ORGANISM(S): Mus musculus

SUBMITTER: Robert Lowe 

PROVIDER: E-GEOD-58733 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress