Perturbed adult sperm methylome after in utero undernutrition is associated with transmission of metabolic disease

ABSTRACT: The pre and postnatal environment can affect both an individual’s risk of adult onset metabolic disease and that of subsequent generations. Although animal models and epidemiological data implicate epigenetic inheritance, little is known of the mechanisms involved. In a robust intergenerational model of developmental programming we demonstrate that the nutritional environment experienced in utero by F1 generation embryos alters the DNA methylome of the F1 adult male germ line in a locus-specific manner, without affecting overall methylation levels. Differentially methylated regions are mostly hypomethylated and are enriched in nucleosome retaining regions in adult sperm. A substantial fraction is resistant to early embryo methylation reprogramming, and thus have the potential to alter

ORGANISM(S): Mus musculus

SUBMITTER: Hui Shi 

PROVIDER: E-GEOD-58747 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress