BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

ABSTRACT: Coordinated BCR-ABL1 kinase-dependent and -independent mechanisms convert p27 from a nuclear tumor suppressor to a cytoplasmic oncogene. Persistence of oncogenic p27 functions despite effective inhibition of BCR-ABL1 may contribute to resistance to tyrosine kinase inhibitors. BCR-ABL1 induced p27 versus knockout, controlling with Empty vector p27 versus knock out

ORGANISM(S): Mus musculus

SUBMITTER: Sophia Jeng 

PROVIDER: E-GEOD-59168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress