Prediction of antibiotic resistance by large-scale phenotypic and genotypic data

ABSTRACT: The evolution of antibiotic resistance is a clear example of adaptation by natural selection. Although a number of mutations contributing to the resistance have been identified, the relationship between the mutations and the related phenotypic changes responsible for the resistance has yet to be fully elucidated. To better characterize phenotype-genotype mapping for drug resistance, we performed parallel laboratory evolution of Escherichia coli under the selection of single antibiotics and after 90 days propagation obtained resistant strains. We find that an acquisition of resistance to one drug drastically changes the resistance and susceptibility to other drugs. Based on transcriptome data of these strains, we demonstrated that the resistances could be quantitatively predicted by the exp

ORGANISM(S): Escherichia coli

SUBMITTER: Chikara Furusawa 

PROVIDER: E-GEOD-59408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress