Neural Stem/Progenitor Cell Properties of Glial Cells in the Adult Auditory Nerve [ouabain]

ABSTRACT: Spiral ganglion neurons (SGNs) and the associated components of the auditory nerve are primary carriers of auditory information from hair cells to the brain. Loss of SGNs occurs with many pathological conditions, resulting in permanent sensorineural hearing loss. Neural stem/progenitors (NSPs) have been well-characterized in several locations of adult brain and retina. However, it is unclear whether NSPs are present in the adult auditory nerve. Here we examined the self-renewal potential of the adult auditory nerve using ouabain application as a well-established mouse model of acute SGN injury. The observed increase in cell proliferation, alteration in enchromatin/heterochromatin ratio and down-regulation of histone deacetylase expression in glial cells suggest that the quiescent glia

ORGANISM(S): Mus musculus

SUBMITTER: Jeremy Barth 

PROVIDER: E-GEOD-59416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress