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MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

ABSTRACT: We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts to treat normal pressure hydrocephalus. We then used RNA-Seq to compare expression patterns between geographically distinct regions of gliomas and computational deconvolution to estimate cell type-specific expression patterns in different disease subtypes. RNA-Seq analysis in 39 contrast-enhancing glioma core samples, 36 non-enhancing FLAIR glioma margin samples, and 17 non-neoplastic brain tissue samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Sims 

PROVIDER: E-GEOD-59612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma.

Gill Brian J BJ   Pisapia David J DJ   Malone Hani R HR   Goldstein Hannah H   Lei Liang L   Sonabend Adam A   Yun Jonathan J   Samanamud Jorge J   Sims Jennifer S JS   Banu Matei M   Dovas Athanassios A   Teich Andrew F AF   Sheth Sameer A SA   McKhann Guy M GM   Sisti Michael B MB   Bruce Jeffrey N JN   Sims Peter A PA   Canoll Peter P  

Proceedings of the National Academy of Sciences of the United States of America 20140811 34

Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical resection impossible. The mixture of neoplastic and nonneoplastic cells that remain after surgery form the biological context for adjuvant therapeutic intervention and recurrence. We performed RNA-sequencing (RNA-seq) and histological analysis on radiographically guided biopsies taken from different regions of GBM and showed that the tissue contained within the contrast-enhancing (CE) core of tumors have dif  ...[more]

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