Trivalent arsenic inhibits the functions of chaperonin complex
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Daniel Yuan
PROVIDER: E-GEOD-5973 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Trivalent arsenic inhibits the functions of chaperonin complex.
Pan Xuewen X Reissman Stefanie S Douglas Nick R NR Huang Zhiwei Z Yuan Daniel S DS Wang Xiaoling X McCaffery J Michael JM Frydman Judith J Boeke Jef D JD
Genetics 20100726 2
The exact molecular mechanisms by which the environmental pollutant arsenic works in biological systems are not completely understood. Using an unbiased chemogenomics approach in Saccharomyces cerevisiae, we found that mutants of the chaperonin complex TRiC and the functionally related prefoldin complex are all hypersensitive to arsenic compared to a wild-type strain. In contrast, mutants with impaired ribosome functions were highly arsenic resistant. These observations led us to hypothesize tha ...[more]
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