P. falciparum Complicated Malaria: Modulation and Connectivity between Exportome and Variant Surface Gene Families

ABSTRACT: In temperate and sub-tropical regions of Latin America, complicated malaria manifested as hepatic dysfunction or renal dysfunction is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated malaria in children, much less is known about it in adults. This can be attributed to many factors: one of which is the expression of clonally variant families of adhesion proteins: PfEMP1 on the iRBC surface. We report here, the analysis of data from a custom, cross strain microarray (Agilent Platform) using material from patient samples, showing hepatic dysfunction or renal failure. These are the most common manifestations seen in adults along with cerebral malaria. The data has been analyzed with reference to variable surfac

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Ashis Das 

PROVIDER: E-GEOD-59844 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress