Progestin-containing Contraceptives Alter Expression of Host Defense-related Genes of the Endometrium and Cervix

ABSTRACT: Epidemiological studies indicate that progestin-containing contraceptives may increase susceptibility to HIV and other infections; however, underlying mechanisms involving the upper female reproductive tract are undefined. To determine the effects of depot medroxyprogesterone acetate (DMPA) and the levonorgestrel intrauterine system (LNG-IUS) on gene expression and physiology of the human endometrial and cervical transformation zone (TZ), microarray analyses were performed on whole tissue biopsies. In endometrium, activated pathways included leukocyte chemotaxis, attachment, and inflammation in DMPA (z>2.5) and LNG-IUS (z>3.5) users, and regulation of pattern recognition receptors and other immune mediators. In cervical TZ, progestin treatment altered expression of tissue remodeling and vi

ORGANISM(S): Homo sapiens

SUBMITTER: Linda Giudice 

PROVIDER: E-GEOD-60129 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress